Immunogen
Synthesized peptide derived from human PHAR3 AA range: 260-310
Specificity
This antibody detects endogenous levels of PHAR3 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Function
induction:Down-regulated in HL-60 leukemia cells by RA, PMA and dimethyl sulfoxide.,similarity:Belongs to the phosphatase and actin regulator family.,similarity:Contains 4 RPEL repeats.,subcellular location:Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.,subunit:Binds actin and PPP1CA; thus inhibiting the protein phosphatase 1 (PP1) activity.,tissue specificity:Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U937, GOTO and HL-60 leukemia cells.,
Gene Name
PHACTR3 C20orf101 SCAPIN1
Human protein sequence Database
Q96KR7
Mouse protein sequence database
Q8BYK5
Rat protein sequence database
Q6RFY2
Cellular localization
Nucleus matrix. Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.
Tissue expression
Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL-60 leukemia cells.
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