Molecular weight (DA)
120kD
Immunogen
Purified recombinant human Phostensin protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of Phostensin and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008],
Function
function:May target protein phosphatase 1 to F-actin cytoskeleton.,subunit:Interacts with Protein phosphatase 1 (PP1).,tissue specificity:Predominantly expressed in leukocytes and spleen.,
Other name
HKMT1098;KIAA1949;Protein phosphatase 1 F actin cytoskeleton targeting subunit.
Human protein sequence Database
Q6NYC8
Mouse protein sequence database
Q8BQ30
Rat protein sequence database
Cellular localization
[Isoform 1]: Cytoplasm, cytoskeleton .; [Isoform 4]: Cytoplasm, cytoskeleton .
Tissue expression
Isoform 4 is predominantly expressed in leukocytes and spleen.
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