Molecular weight (DA)
Molecular Weight
Calculated MW: 131 kDa; Observed MW: 160 kDa
Immunogen
Purified recombinant human HDAC6 protein expressed in E.coli.
Dilution rate
WB: 1/500-1/1000
Purification process (Immunogen)
Background
Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
Other name
HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
Human gene ID
SwissProt ID
Q9UBN7
Human protein sequence Database
Gene ID
10013
Mouse protein sequence database
Rat protein sequence database
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.