Molecular weight (DA)
70kD
Immunogen
Purified recombinant human RPA70 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of RPA70 and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb dilution 1:1000 icc dilution 1:100
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
function:It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein. Absolutely required for simian virus 40 DNA replication in vitro.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the replication factor A protein 1 family.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Interacts with RIP and XPA. Interacts with RPA4.,
Function
function:It participates in a very early step in initiation. RP-A is a single-stranded DNA-binding protein. Absolutely required for simian virus 40 DNA replication in vitro.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the replication factor A protein 1 family.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Interacts with RIP and XPA. Interacts with RPA4.,
Other name
Dmrpa1;Drosophila Replication Protein A;DRPA;DSSB;HSSB;Human single stranded DNA binding protein;MST075;MSTP075;p70;REPA 1;REPA1;Replication factor A;Replication factor A protein 1;Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70kDa DNA binding subunit;Replication protein A1 (70kD);Replication protein A1 (70kD); Replication protein A1 70kDa;Replication protein A1;RF A;RF-A protein 1;RFA;RFA1_HUMAN; RP A;RP-A p70;RPA 1;RPA 70;RPA;RPA1;Single stranded binding protein 70;Single stranded DNA binding protein;Single-stranded DNA-binding protein;Ssb70.
Fields
>>DNA replication;>>Nucleotide excision repair;>>Mismatch repair;>>Homologous recombination;>>Fanconi anemia pathway
Human protein sequence Database
P27694
Mouse protein sequence database
Q8VEE4
Rat protein sequence database
Cellular localization
Nucleus . Nucleus, PML body . Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. .
Tissue expression
Aorta,Aortic endothelium,Lung carcinoma,Uterus,
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