Immunogen
Synthesized peptide derived from human Thyroid Peroxidase(TPO)
Specificity
This antibody detects endogenous levels of Thyroid Peroxidase(TPO) at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
Function
alternative products:Additional isoforms seem to exist,catalytic activity:2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.,disease:Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.,function:Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).,online information:Thyroid peroxidase entry,pathway:Hormone b
Protein name
Thyroid Peroxidase(TPO)
Abbreviation
Thyroid Peroxidase
Other name
Thyroid peroxidase (TPO;EC 1.11.1.8)
Fields
>>Tyrosine metabolism;>>Metabolic pathways;>>Thyroid hormone synthesis;>>Autoimmune thyroid disease
Human protein sequence Database
P07202
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface.
Tissue expression
Glandular pool- thyroid,Spleen,Thyroid,
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