Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from human TRP2 DCT
Specificity
This antibody detects endogenous levels of TRP2 DCT at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.28% sodium azide.
Dilution rate
IHC-p1:50-200 ,WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Function
catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,
Other name
L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2)
Fields
>>Tyrosine metabolism;>>Metabolic pathways;>>Melanogenesis
Human protein sequence Database
P40126
Mouse protein sequence database
P29812
Rat protein sequence database
Cellular localization
Melanosome membrane ; Single-pass type I membrane protein . Melanosome . Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. .
Tissue expression
Liver,Lymphnode melanoma metastases,Mammary gland,Melanoma,
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