Molecular weight (DA)
74kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 320-400
Specificity
KIZ Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
kizuna centrosomal protein(KIZ) Homo sapiens The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013],
Function
microtubule cytoskeleton organization, cytoskeleton organization, microtubule-based process, cell cycle, cell cycle process, microtubule organizing center organization, spindle pole body organization,
Gene Name
PLK1S1 C20orf19 KIZ NCRNA00153 HT013
Protein name
Centrosomal protein kizuna (Polo-like kinase 1 substrate 1)
Human protein sequence Database
Q2M2Z5
Mouse protein sequence database
Q3UXL4
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body . Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule-independent and dependent manner, respectively. .
Tissue expression
Uterus,
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