Molecular weight (DA)
64kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 370-450
Specificity
SYN2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. Polymorphisms in this gene are associated with abnormal presynaptic function and related neuronal disorders, including autism, epilepsy, bipolar disorder and schizophrenia. Alternative splicing of this gene results in multiple transcript variants. The tissue inhibitor of metalloproteinase 4 gene is located within an intron of this gene and is transcribed in the opposite direction.
Function
caution:There are several mRNAs and ESTs supporting this gene model. However the genome sequence encoding the N-terminal part contains several sequence discrepencies.,function:Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release.,sequence caution:Several in-frame stop codons.,similarity:Belongs to the synapsin family.,subunit:Interacts with CAPON.,tissue specificity:Central and peripheral nervous systems.,
Protein name
Synapsin-2 (Synapsin II)
Human protein sequence Database
Q92777
Mouse protein sequence database
Q64332
Rat protein sequence database
Q63537
Cellular localization
Cell junction, synapse.
Tissue expression
Central and peripheral nervous systems.
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