Molecular weight (DA)
82kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 260-340
Specificity
MTF1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008],
Function
function:Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).,similarity:Contains 6 C2H2-type zinc fingers.,
Protein name
Metal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1)
Human protein sequence Database
Q14872
Mouse protein sequence database
Q07243
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Translocation to the nucleus is induced by metals. .
Tissue expression
Liver,Muscle,
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