Molecular weight (DA)
13kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
ANFC Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015],
Function
function:Vasorelaxant activity. Has a cGMP-stimulating activity.,similarity:Belongs to the natriuretic peptide family.,
Protein name
C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53]
Fields
>>cGMP-PKG signaling pathway;>>Vascular smooth muscle contraction;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P23582
Mouse protein sequence database
Q61839
Rat protein sequence database
P55207
Cellular localization
Secreted.
Tissue expression
[CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level).
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