Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 50-130
Specificity
PGFRL Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008],
Function
disease:Defects in PDGFRL are associated with colorectal cancer (CRC) [MIM:114500].,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in colon, lung and liver.,
Protein name
Platelet-derived growth factor receptor-like protein (PDGFR-like protein) (PDGF receptor beta-like tumor suppressor)
Human protein sequence Database
Q15198
Mouse protein sequence database
Q6PE55
Rat protein sequence database
Q5RJP7
Cellular localization
Secreted .
Tissue expression
Expressed in colon, lung and liver.
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