Molecular weight (DA)
54kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 290-370
Specificity
HSF4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
heat shock transcription factor 4(HSF4) Homo sapiens Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008],
Function
disease:Defects in HSF4 are the cause of lamellar cataract [MIM:116800]; also known as Marner type cataract (CAM). Lamellar cataract is an autosomal dominant common type of infantile cataract. Finger malformation is observed in some kindreds.,function:DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.,PTM:Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-299. HSFA is not sumoylated.,PTM:Phosphorylated mainly on serine residues. Phosphorylation on Ser-299 promotes sumoylation on Lys-294.,similarity:Belongs to the HSF family.,subunit:Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts with DUSP26, MAPK1, MAPK2 and MAP kinase p38.,tissue s
Protein name
Heat shock factor protein 4 (HSF 4) (hHSF4) (Heat shock transcription factor 4) (HSTF 4)
Human protein sequence Database
Q9ULV5
Mouse protein sequence database
Q9R0L1
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues.
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