Molecular weight (DA)
14kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 50-130
Specificity
LSM1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
LSM1 homolog, mRNA degradation associated(LSM1) Homo sapiens This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011],
Function
function:Binds specifically to the 3'-terminal U-tract of U6 snRNA.,similarity:Belongs to the snRNP Sm proteins family.,subunit:LSm subunits form a heteromer with a donut shape.,tissue specificity:Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.,
Protein name
U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)
Human protein sequence Database
O15116
Mouse protein sequence database
Q8VC85
Rat protein sequence database
Cellular localization
Cytoplasm . Cytoplasm, P-body .
Tissue expression
Eye,Lymph node,
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