Molecular weight (DA)
75kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 470-550
Specificity
RNF6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008],
Function
similarity:Contains 1 RING-type zinc finger.,tissue specificity:Weakly expressed in peripheral blood, spleen, prostate, testis and ovary.,
Protein name
E3 ubiquitin-protein ligase RNF6 (EC 6.3.2.-)
Human protein sequence Database
Q9Y252
Mouse protein sequence database
Q9DBU5
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Cell projection, axon . Nucleus, PML body . Localizes to the PML nuclear bodies in Sertoli cells. .
Tissue expression
Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
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