Molecular weight (DA)
35kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 180-260
Specificity
MAFB Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns. [provided by RefSeq, Jul 2008],
Function
domain:The leucine-zipper domain is involved in the interaction with LRPICD.,function:Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.,PTM:Phosphorylated by GSK3 and MAPK13 on serine and threonine residues.,PTM:Sumoylated. Su
Protein name
Transcription factor MafB (Maf-B) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog B)
Fields
>>Parathyroid hormone synthesis, secretion and action
Human protein sequence Database
Q9Y5Q3
Mouse protein sequence database
P54841
Rat protein sequence database
P54842
Cellular localization
Nucleus .
Tissue expression
Ubiquitous.
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