Molecular weight (DA)
23kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1-80
Specificity
CALY Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
calcyon neuron specific vesicular protein(CALY) Homo sapiens The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008],
Function
caution:Was originally (PubMed:10698743) thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.,function:Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.,PTM:Glycosylated.,similarity:Belongs to the NSG family.,subunit:Interacts with CLTA.,tissue specificity:Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.,
Protein name
Neuron-specific vesicular protein calcyon
Fields
>>Dopaminergic synapse
Human protein sequence Database
Q9NYX4
Mouse protein sequence database
Q9DCA7
Rat protein sequence database
P58821
Cellular localization
Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.
Tissue expression
Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.
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