Molecular weight (DA)
70kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 220-300
Specificity
K22O Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009],
Function
developmental stage:Synthesized during maturation of epidermal keratinocytes.,function:Probably contributes to terminal cornification.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,sequence caution:Translated as Glu.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,
Gene Name
KRT76 KRT2B KRT2P
Protein name
Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)
Human protein sequence Database
Q01546
Mouse protein sequence database
Q3UV17
Rat protein sequence database
Cellular localization
nucleus,intermediate filament,keratin filament,extracellular exosome,
Tissue expression
Tongue,
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