Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 760-840
Specificity
MAGE1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to mental retardation. [provided by RefSeq, Mar 2010],
Function
similarity:Contains 2 MAGE domains.,
Gene Name
MAGEE1 HCA1 KIAA1587
Protein name
Melanoma-associated antigen E1 (Alpha-dystrobrevin-associated MAGE Protein) (DAMAGE) (Hepatocellular carcinoma-associated protein 1) (MAGE-E1 antigen)
Human protein sequence Database
Q9HCI5
Mouse protein sequence database
Q6PCZ4
Rat protein sequence database
A1A5P9
Cellular localization
Cytoplasm, perinuclear region . Nucleus . Cell membrane . In the skeletal muscle, found at the postsynaptic membrane and is associated with a subset of myonuclei. May reside within nuclei and/or in perinuclear compartments. In peripheral nerves, colocalizes with DTNA in the Schwann cell membrane (By similarity). .
Tissue expression
Brain,PNS,Testis,
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