Molecular weight (DA)
24kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 140-220
Specificity
CIDEA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
cell death-inducing DFFA-like effector a(CIDEA) Homo sapiens This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010],
Function
function:Activates apoptosis.,similarity:Contains 1 CIDE-N domain.,subunit:Inhibited by DFFB.,
Protein name
Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A)
Human protein sequence Database
O60543
Mouse protein sequence database
O70302
Rat protein sequence database
Cellular localization
Lipid droplet . Nucleus . Enriched at lipid droplet contact sites. Has been shown to localize to mitochondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062). .
Tissue expression
Expressed in omental and subcutaneous adipose tissue (at protein level).
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