Molecular weight (DA)
56kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 340-420
Specificity
AGT2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
Function
catalytic activity:(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.,catalytic activity:L-alanine + glyoxylate = pyruvate + glycine.,cofactor:Pyridoxal phosphate.,similarity:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homotetramer.,
Protein name
Alanine--glyoxylate aminotransferase 2, mitochondrial (AGT 2) (EC 2.6.1.44) ((R)-3-amino-2-methylpropionate--pyruvate transaminase) (EC 2.6.1.40) (Beta-ALAAT II) (Beta-alanine-pyruvate aminotransferas
Fields
>>Alanine, aspartate and glutamate metabolism;>>Glycine, serine and threonine metabolism;>>Cysteine and methionine metabolism;>>Valine, leucine and isoleucine degradation;>>Metabolic pathways
Human protein sequence Database
Q9BYV1
Mouse protein sequence database
Q3UEG6
Rat protein sequence database
Q64565
Cellular localization
Mitochondrion .
Tissue expression
Kidney,
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