Molecular weight (DA)
35kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MRGRD Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,subcellular location:Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.,
Function
function:May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,subcellular location:Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.,
Protein name
Mas-related G-protein coupled receptor member D (Beta-alanine receptor) (G-protein coupled receptor TGR7)
Fields
>>Renin-angiotensin system
Human protein sequence Database
Q8TDS7
Mouse protein sequence database
Q91ZB8
Rat protein sequence database
Q7TN41
Cellular localization
Cell membrane ; Multi-pass membrane protein . Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
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