Molecular weight (DA)
57kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 200-280
Specificity
AAA1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008],
Function
disease:Defects in SLC7A10 may be involved in cystinuria (CSNU) which arises from impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract. Three types of cystinuria have been described.,function:Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.,similarity:Belongs to the amino acid-polyamine-organocation (APC) superfamily.,subunit:Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.,tissue specificity:Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.,
Protein name
Asc-type amino acid transporter 1 (Asc-1) (Solute carrier family 7 member 10)
Human protein sequence Database
Q9NS82
Mouse protein sequence database
P63115
Rat protein sequence database
P63116
Cellular localization
Membrane ; Multi-pass membrane protein .
Tissue expression
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
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