Molecular weight (DA)
75kD
Immunogen
The antiserum was produced against synthesized peptide derived from human FZD8. AA range:31-80
Specificity
Frizzled-5/8 Polyclonal Antibody detects endogenous levels of Frizzled-5/8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
frizzled class receptor 5(FZD5) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008],
Function
domain:Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.,domain:The FZ domain is involved in binding with Wnt ligands.,domain:The PDZ-binding motif mediates interaction with GOPC.,function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellul
Protein name
Frizzled-5/8
Abbreviation
Frizzled-5/8
Other name
FZD5; C2orf31; Frizzled-5; Fz-5; hFz5; FzE5; FZD8; Frizzled-8; Fz-8; hFz8
Fields
>>mTOR signaling pathway;>>Wnt signaling pathway;>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>Melanogenesis;>>Cushing syndrome;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Human papillomavirus infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>Basal cell carcinoma;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer
Human protein sequence Database
Q13467/Q9H461
Mouse gene ID
14367/14370
Mouse protein sequence database
Rat gene ID
317674/100909849
Rat protein sequence database
Q8CHL0/Q498S8
Cellular localization
Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cell projection, axon . Localized at the plasma membrane and also found at the Golgi. .
Tissue expression
Oesophageal carcinoma,Retina,
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