Molecular weight (DA)
39kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
POPD1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
blood vessel epicardial substance(BVES) Homo sapiens This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved in the regeneration of adult skeletal muscle and may act as a cell adhesion molecule in coronary vasculogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010],
Function
function:May play an important role in heart development.,similarity:Belongs to the popeye family.,tissue specificity:Expressed in fetal and adult heart and skeletal muscle.,
Gene Name
BVES POP1 POPDC1
Protein name
Blood vessel epicardial substance (hBVES) (Popeye domain-containing protein 1) (Popeye protein 1)
Human protein sequence Database
Q8NE79
Mouse protein sequence database
Q9ES83
Rat protein sequence database
Q3BCU4
Cellular localization
Lateral cell membrane . Cell junction, tight junction . Membrane ; Multi-pass membrane protein . Cell membrane, sarcolemma . Membrane, caveola . Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells. .
Tissue expression
Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle.
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