Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 421-470
Specificity
BMP3B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
growth differentiation factor 10(GDF10) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016],
Function
similarity:Belongs to the TGF-beta family.,subunit:Homodimer or heterodimer .,tissue specificity:Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.,
Protein name
Bone morphogenetic protein 3B (BMP-3B) (Bone-inducing protein) (BIP) (Growth/differentiation factor 10) (GDF-10)
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
P55107
Mouse protein sequence database
P97737
Rat protein sequence database
P55108
Cellular localization
Secreted .
Tissue expression
Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
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