Molecular weight (DA)
48kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CBPA6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The gene encodes a member of the peptidase M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which catalyzes the release of large hydrophobic C-terminal amino acids. This enzyme has functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Mutations in this gene may be linked to epilepsy and febrile seizures, and a translocation t(6;8)(q26;q13) involving this gene has been associated with Duane retraction syndrome. [provided by RefSeq, May 2016],
Function
catalytic activity:Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.,cofactor:Binds 1 zinc ion per subunit.,disease:A chromosomal aberration disrupting CPA6 was found in a patient with Duane retraction syndrome (DURS) [MIM:126800]. Translocation t(6;8)(q26;q13).,similarity:Belongs to the peptidase M14 family.,
Protein name
Carboxypeptidase A6 (EC 3.4.17.1) (Carboxypeptidase B)
Human protein sequence Database
Q8N4T0
Mouse protein sequence database
Q5U901
Rat protein sequence database
Cellular localization
Secreted, extracellular space, extracellular matrix .
Tissue expression
Expressed in the hippocampus, nucleus raphe, and cortex.
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