Molecular weight (DA)
40kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CNTFR Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011],
Function
domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Binds to CNTF. The alpha chain provides the receptor specificity.,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterotrimer of the alpha chain, LIFR and IL6ST.,tissue specificity:Nervous system and skeletal muscle.,
Protein name
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Fields
>>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway
Human protein sequence Database
P26992
Mouse protein sequence database
O88507
Rat protein sequence database
Q08406
Cellular localization
Cell membrane; Lipid-anchor, GPI-anchor.
Tissue expression
Nervous system and skeletal muscle.
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