Molecular weight (DA)
12kD
Immunogen
Synthesized peptide derived from part region of human protein AA range: 1-50
Specificity
DYLT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
dynein light chain Tctex-type 1(DYNLT1) Homo sapiens This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014],
Function
similarity:Belongs to the dynein light chain Tctex-type family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains. Found in a complex with SCN10A. Interacts with DOC2A, DOC2B and SCN10A (By similarity). Interacts with PVR.,tissue specificity:Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon.,
Gene Name
DYNLT1 TCTEL1 TCTEX-1 TCTEX1
Protein name
Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog)
Fields
>>Salmonella infection
Human protein sequence Database
P63172
Mouse protein sequence database
P51807
Rat protein sequence database
Q9Z336
Cellular localization
Golgi apparatus . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Localizes to mitotic spindles. .
Tissue expression
Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).
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