Molecular weight (DA)
99kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
HACE1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016],
Function
developmental stage:Expressed in fetal and pediatric kidney cells.,function:E3 ubiquitin-protein ligase that may function in cellular proteins degradation.,induction:Down-regulated in sporadic Wilms tumor.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 6 ANK repeats.,subcellular location:A significant portion localizes to the endoplasmic reticulum.,subunit:Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.,tissue specificity:Expressed in multiple tissues including heart, brain and kidney.,
Protein name
E3 ubiquitin-protein ligase HACE1 (EC 6.3.2.-) (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1)
Human protein sequence Database
Q8IYU2
Mouse protein sequence database
Q3U0D9
Rat protein sequence database
D3ZBM7
Cellular localization
Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
Tissue expression
Expressed in multiple tissues including heart, brain and kidney.
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