Molecular weight (DA)
162kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
FYCO1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
FYVE and coiled-coil domain containing 1(FYCO1) Homo sapiens This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011],
Function
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 GOLD domain.,similarity:Contains 1 RUN domain.,tissue specificity:Expressed in heart and skeletal muscle.,
Protein name
FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7)
Fields
>>Salmonella infection
Human protein sequence Database
Q9BQS8
Mouse protein sequence database
Q8VDC1
Rat protein sequence database
Cellular localization
Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.
Tissue expression
Expressed in heart and skeletal muscle.
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