Molecular weight (DA)
39kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
GNA11 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013],
Function
function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.,similarity:Belongs to the G-alpha family. G(q) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.,
Protein name
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (Guanine nucleotide-binding protein G(y) subunit alpha)
Fields
>>Calcium signaling pathway;>>cGMP-PKG signaling pathway;>>Vascular smooth muscle contraction;>>Gap junction;>>Cholinergic synapse;>>Long-term depression;>>Insulin secretion;>>GnRH signaling pathway;>>Aldosterone synthesis and secretion;>>Cortisol synthesis and secretion;>>Parathyroid hormone synthesis, secretion and action;>>GnRH secretion;>>Cushing syndrome;>>Growth hormone synthesis, secretion and action;>>Chagas disease;>>Amoebiasis;>>Human cytomegalovirus infection;>>Human immunodeficiency virus 1 infection;>>Pathways in cancer
Human protein sequence Database
P29992
Mouse protein sequence database
P21278
Rat protein sequence database
Q9JID2
Cellular localization
Cell membrane ; Lipid-anchor . Cytoplasm . In testicular cells, expressed exclusively in the cytoplasm.
Tissue expression
Expressed in testis.
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