Molecular weight (DA)
81kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 210-290
Specificity
TRFM Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008],
Function
function:Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.,similarity:Belongs to the transferrin family.,similarity:Contains 2 transferrin-like domains.,tissue specificity:Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.,
Protein name
Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)
Human protein sequence Database
P08582
Mouse protein sequence database
Q9R0R1
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.
Tissue expression
Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.
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