Molecular weight (DA)
71kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
FLRT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
fibronectin leucine rich transmembrane protein 1(FLRT1) Homo sapiens This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008],
Function
function:May have a function in cell adhesion and/or receptor signaling.,PTM:N-glycosylated.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Expressed in kidney and brain.,
Gene Name
FLRT1 UNQ752/PRO1483
Protein name
Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin-like domain-containing leucine-rich transmembrane protein 1)
Human protein sequence Database
Q9NZU1
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane . Cytoplasmic vesicle membrane . Cytoplasm, perinuclear region . Cell junction, focal adhesion . Secreted . Cell projection, neuron projection . Cell junction . In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain. .
Tissue expression
Expressed in kidney and brain.
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