Molecular weight (DA)
28kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RAB18. AA range:103-152
Specificity
Rab 18 Polyclonal Antibody detects endogenous levels of Rab 18 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012],
Function
function:Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes.,similarity:Belongs to the small GTPase superfamily. Rab family.,tissue specificity:Ubiquitous.,
Protein name
Ras-related protein Rab-18
Other name
RAB18; Ras-related protein Rab-18
Human protein sequence Database
Q9NP72
Mouse protein sequence database
P35293
Rat protein sequence database
Q5EB77
Cellular localization
Apical cell membrane . Lipid droplet .
Tissue expression
Ubiquitous.
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