Molecular weight (DA)
43kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 150-230
Specificity
P2RX1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013],
Function
disease:Defects in P2RX1 are a cause of bleeding disorder [MIM:600845].,function:Ligand gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death.,online information:P2RX1 entry,online information:P2X receptor entry,similarity:Belongs to the P2X receptor family.,subunit:Homo- or heteropolymers.,
Protein name
P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor)
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Platelet activation
Human protein sequence Database
P51575
Mouse protein sequence database
P51576
Rat protein sequence database
P47824
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Blood,Lung,Placenta,Platelet,Urinary bladder,Urinary bladder smooth muscle,
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