Molecular weight (DA)
105kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 400-480
Specificity
PACS1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008],
Function
function:Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the PACS family.,subcellular location:Localizes in the perinuclear region, probably the TGN.,subunit:Interacts with HIV-1 Nef, AP-1 and AP-3 but not with AP-2. Forms a ternary complex with furin and AP-1. Combines with Nef to usurp the ARF6 endocytic pathway by a PI3K-dependent process to remove cell surface MHC-I molecules.,
Protein name
Phosphofurin acidic cluster sorting protein 1 (PACS-1)
Human protein sequence Database
Q6VY07
Mouse protein sequence database
Q8K212
Rat protein sequence database
O88588
Cellular localization
Golgi apparatus, trans-Golgi network . Localizes in the perinuclear region, probably the TGN. .
Tissue expression
Brain,Embryo,Epithelium,Fetal brain,Kidney,Testis,Uterus,
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