Molecular weight (DA)
19kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NBL1. AA range:131-180
Specificity
DAN Polyclonal Antibody detects endogenous levels of DAN protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013],
Function
disease:Defects in NBL1 are possibly the cause of the development and/or progression of human neuroblastoma.,function:Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.,similarity:Belongs to the DAN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,tissue specificity:Most abundant in normal lung and meningioma.,
Protein name
Neuroblastoma suppressor of tumorigenicity 1
Other name
NBL1; DAN; DAND1; Neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; Protein N03; Zinc finger protein DAN
Fields
>>TGF-beta signaling pathway
Human protein sequence Database
P41271
Mouse protein sequence database
Q61477
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Most abundant in normal lung and meningioma.
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