Molecular weight (DA)
46kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 50-130
Specificity
CLP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],
Function
catalytic activity:ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.,catalytic activity:ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA.,cofactor:Magnesium, manganese or nickel.,function:Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage compl
Protein name
Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)
Fields
>>mRNA surveillance pathway
Human protein sequence Database
Q92989
Mouse protein sequence database
Q99LI9
Rat protein sequence database
Q5PQL4
Cellular localization
Nucleus .
Tissue expression
Lung,Placenta,
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