Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 290-370
Specificity
SFTPD Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015],
Function
function:Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.,miscellaneous:Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).,online information:Pulmonary surfactant protein SP-D,PTM:Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.,PTM:The N-terminus is blocked.,similarity:Belongs to the SFTPD family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 collagen-like domain.,subunit:Oligomeric complex of 4 set o
Gene Name
SFTPD COLEC7 PSPD SFTP4
Protein name
Pulmonary surfactant-associated protein D (PSP-D) (SP-D) (Collectin-7) (Lung surfactant protein D)
Human protein sequence Database
P35247
Mouse protein sequence database
P50404
Rat protein sequence database
P35248
Cellular localization
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
Tissue expression
Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).
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