Molecular weight (DA)
47kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 320-400
Specificity
NSUN5 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],
Function
function:May have S-adenosyl-L-methionine-dependent methyl-transferase activity .,PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the methyltransferase superfamily. RsmB/NOP family.,tissue specificity:Ubiquitous. Detected in placenta, heart and skeletal muscle.,
Gene Name
NSUN5 WBSCR20 WBSCR20A
Protein name
Putative methyltransferase NSUN5 (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)
Human protein sequence Database
Q96P11
Mouse protein sequence database
Q8K4F6
Rat protein sequence database
Cellular localization
Nucleus, nucleolus .
Tissue expression
Ubiquitous (PubMed:11978965, PubMed:12073013). Detected in placenta, heart and skeletal muscle (PubMed:11978965, PubMed:12073013).
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