Molecular weight (DA)
87kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 550-630
Specificity
RINT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
developmental stage:Expressed throughout the cell cycle.,function:Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control.,miscellaneous:According to PubMed:11096100, a longer form, which may be due to the differential initiation of translation using a non-AUG codon, may exist. However, the existence of such form has not been clearly demonstrated.,similarity:Belongs to the RINT1 family.,similarity:Contains 1 RINT1/TIP20 domain.,subunit:Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. Interacts directly with BNIP1/SEC20L and ZW10. Interacts with RAD50 during late S and G2/M phases. Interacts with RBL2, preferentially with the active, hypophosphorylated form.,
Function
developmental stage:Expressed throughout the cell cycle.,function:Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control.,miscellaneous:According to PubMed:11096100, a longer form, which may be due to the differential initiation of translation using a non-AUG codon, may exist. However, the existence of such form has not been clearly demonstrated.,similarity:Belongs to the RINT1 family.,similarity:Contains 1 RINT1/TIP20 domain.,subunit:Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. Interacts directly with BNIP1/SEC20L and ZW10. Interacts with RAD50 during late S and G2/M phases. Interacts with RBL2, preferentially with the active, hypophosphorylated form.,
Protein name
RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1)
Human protein sequence Database
Q6NUQ1
Mouse protein sequence database
Q8BZ36
Rat protein sequence database
Cellular localization
Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
Tissue expression
B-cell,Brain,Embryo,Testis,
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