Molecular weight (DA)
88kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 170-250
Specificity
RASL1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010],
Function
function:Probable inhibitory regulator of the Ras-cyclic AMP pathway.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains.,tissue specificity:Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea.,
Protein name
RasGAP-activating-like protein 1
Fields
>>Ras signaling pathway
Human protein sequence Database
O95294
Mouse protein sequence database
Q9Z268
Rat protein sequence database
Cellular localization
intracellular,cytosol,plasma membrane,intrinsic component of the cytoplasmic side of the plasma membrane,
Tissue expression
Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea (PubMed:9751798). Expressed in melanocytes (PubMed:23999003).
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