Molecular weight (DA)
67kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
S6A12 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subunit:Interacts with LIN7C.,tissue specificity:Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.,
Function
function:Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subunit:Interacts with LIN7C.,tissue specificity:Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.,
Protein name
Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12)
Fields
>>Synaptic vesicle cycle;>>GABAergic synapse
Human protein sequence Database
P48065
Mouse protein sequence database
P31651
Rat protein sequence database
P48056
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.
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