Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
S6A20 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008],
Function
function:Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subcellular location:Located in the apical brush border membrane of kidney proximal tubule cells.,tissue specificity:Kidney and small intestine.,
Gene Name
SLC6A20 SIT1 XT3 XTRP3
Protein name
Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog)
Human protein sequence Database
Q9NP91
Mouse protein sequence database
Rat protein sequence database
Q64093
Cellular localization
Apical cell membrane ; Multi-pass membrane protein . Located in the apical brush border membrane of kidney proximal tubule cells. .
Tissue expression
Kidney and small intestine. Expressed in the S3 segment of the proximal tubule.
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