Molecular weight (DA)
68kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
SC6A3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009],
Function
function:Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,online information:Dopamine transporter entry,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subunit:Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1.,
Protein name
Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)
Fields
>>Synaptic vesicle cycle;>>Dopaminergic synapse;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases;>>Cocaine addiction;>>Amphetamine addiction;>>Alcoholism
Human protein sequence Database
Q01959
Mouse protein sequence database
Q61327
Rat protein sequence database
P23977
Cellular localization
Cell membrane ; Multi-pass membrane protein . Cell projection, neuron projection . Cell projection, axon . Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity). .
Tissue expression
Highly expressed in substantia nigra (PubMed:7637582). Expressed in axonal varicosities in dopaminergic nerve terminals (at protein level) (PubMed:17296554). Expressed in the striatum (at protein level) (PubMed:17296554).
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