Molecular weight (DA)
55kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
UBAP1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],
Function
similarity:Contains 2 UBA domains.,tissue specificity:Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.,
Protein name
Ubiquitin-associated protein 1 (UBAP-1) (Nasopharyngeal carcinoma-associated gene 20 protein)
Human protein sequence Database
Q9NZ09
Mouse protein sequence database
Q8BH48
Rat protein sequence database
Q5XIS7
Cellular localization
Cytoplasm, cytosol . Endosome . Predominantly cytosolic (PubMed:21757351). Recruited to endosomes as part of the ESCRT-I complex (PubMed:21757351). .
Tissue expression
Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.
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