Molecular weight (DA)
83kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 590-670
Specificity
CUL4A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009],
Function
function:Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(
Protein name
Cullin-4A (CUL-4A)
Fields
>>Nucleotide excision repair;>>Ubiquitin mediated proteolysis;>>Human immunodeficiency virus 1 infection
Human protein sequence Database
Q13619
Mouse protein sequence database
Q3TCH7
Rat protein sequence database
Cellular localization
nucleoplasm,cullin-RING ubiquitin ligase complex,Cul4A-RING E3 ubiquitin ligase complex,Cul4-RING E3 ubiquitin ligase complex,
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