Molecular weight (DA)
20kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 30-110
Specificity
GKN2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015],
Function
similarity:Contains 1 BRICHOS domain.,subunit:Interacts with TFF2 (By similarity). Heterodimer with TFF1; disulfide linked.,tissue specificity:Expressed in gastric mucosa.,
Gene Name
GKN2 BLOT GDDR TFIZ1 UNQ465/PRO813
Protein name
Gastrokine-2 (Blottin) (Down-regulated in gastric cancer) (Trefoil factor interactions(z) 1)
Human protein sequence Database
Q86XP6
Mouse protein sequence database
Q9CQS6
Rat protein sequence database
Q29TV8
Cellular localization
Secreted.
Tissue expression
Expressed in gastric mucosa.
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