Molecular weight (DA)
114kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 910-990
Specificity
PEAR1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008],
Function
function:When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.,PTM:Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.,similarity:Belongs to the MEGF family.,similarity:Contains 1 EMI domain.,similarity:Contains 9 EGF-like domains.,subcellular location:Detected on the cell surface in resting platelets.,subunit:Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation.,tissue specificity:Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas
Protein name
Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12)
Human protein sequence Database
Q5VY43
Mouse protein sequence database
Q8VIK5
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass membrane protein . Detected on the cell surface in resting platelets. .
Tissue expression
Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.
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