Molecular weight (DA)
51kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 330-410
Specificity
HNF6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
Function
function:Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.,online information:Hepatocyte nuclear factors entry,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 CUT DNA-binding domain.,similarity:Contains 1 homeobox DNA-binding domain.,subunit:Binds DNA as a monomer.,tissue specificity:Highly expressed in liver; lower expression in testis and skin.,
Gene Name
ONECUT1 HNF6 HNF6A
Protein name
Hepatocyte nuclear factor 6 (HNF-6) (One cut domain family member 1) (One cut homeobox 1)
Fields
>>Signaling pathways regulating pluripotency of stem cells;>>Maturity onset diabetes of the young
Human protein sequence Database
Q9UBC0
Mouse protein sequence database
O08755
Rat protein sequence database
P70512
Cellular localization
Nucleus.
Tissue expression
Highly expressed in liver; lower expression in testis and skin.
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